清毒百炎消外敷对蝮蛇咬伤患者患肢肿胀、疼痛及心肌酶谱水平的影响

Effect of Qingdu Baiyanxiao external application on limb swelling, pain, and myocardial enzyme levels in patients with pit viper bite

摘要:

目的 探讨清毒百炎消外敷对蝮蛇咬伤患者患肢肿胀、疼痛及心肌酶谱水平的影响。方法 回顾性分析2020年1月至2023年12月九江市第一人民医院收治的85例蝮蛇咬伤患者的临床资料，按照治疗方式不同分为两组。对照组（n=43）采用常规西医治疗，观察组（n=42）采用常规西医联合清毒百炎消外敷治疗，治疗7 d后观察治疗效果。比较两组临床疗效、患肢肿胀、疼痛、心肌酶谱水平、炎症指标、局部症状、全身症状及不良反应发生情况。结果 观察组临床疗效优于对照组，且治愈率高于对照组（P＜0.05）；治疗后，观察组患肢肿胀程度、视觉模拟评分（VAS）、局部症状积分、全身症状积分及肌酸激酶同工酶（CK-MB）、肌酸激酶（CK）、乳酸脱氢酶（LDH）、超敏C反应蛋白（hs-CRP）、中性粒细胞、白细胞水平均较对照组低（P＜0.05）；两组未见明显不良反应。结论 清毒百炎消外敷治疗可减轻蝮蛇咬伤患者患肢肿胀、疼痛，改善心肌酶谱水平，抑制炎症反应，缓解临床症状，安全性好，为临床治疗蝮蛇咬伤提供一定的参考。

Abstract:

Objective To investigate the effects of Qingdu Baiyanxiao external application on limb swelling, pain, and myocardial enzyme levels in patients with pit viper bite.Methods A retrospective analysis was conducted on the clinical data of 85 patients with pit viper bites admitted to Jiujiang First People's Hospital from January 2020 to December 2023. They were divided into two groups according to different treatment methods. 43 cases in the control group were treated with conventional Western medicine, while 42 cases in the observation group were treated with external application of Qingdu Baiyanxiao and Western medicine. The treatment effect was observed after 7 days of treatment. The clinical efficacy, limb swelling, pain, myocardial enzyme levels, inflammatory indicators, local symptoms, systemic symptoms, and adverse reactions between two groups were compared.Results The clinical efficacy of the observation group was better than that of the control group, and the cure rate was higher than that of the control group (P＜0.05). After treatment, the observation group showed lower levels of limb swelling, visual analog scale (VAS), local symptom score, systemic symptom score, creatine kinase isoenzyme (CK-MB), creatine kinase (CK), lactate dehydrogenase (LDH), high-sensitivity C-reactive protein (hs-CRP), neutrophils, and white blood cells compared to the control group (P＜0.05). No significant adverse reactions were observed in both groups.Conclusion The external application of Qingdu Baiyanxiao can alleviate swelling and pain in the affected limbs of patients with pit viper bites, improve myocardial enzyme levels, inhibit inflammatory reactions, alleviate clinical symptoms, and has good safety. It provides a certain reference for the clinical treatment of pit viper bites.