rhEGF凝胶联合水凝胶敷料对烧伤后瘢痕皮肤软组织扩张术后患者创面愈合及生长因子的影响

Effect of rhEGF gel combined with hydrogel dressing on wound healing and growth factors in patients underwent scar skin and soft tissue expansion surgery after burn injury

摘要:

目的 探讨重组人表皮生长因子凝胶（rhEGF）联合水凝胶敷料对烧伤后瘢痕皮肤软组织扩张术后患者的影响。方法 以随机数字表法将2021年8月至2024年8月在江南大学附属医院就诊的92例烧伤后瘢痕皮肤软组织扩张术后患者分为两组，每组46例。对照组采用水凝胶敷料外敷，观察组采用水凝胶联合rhEGF凝胶敷料外敷。治疗3周后，对比两组创面愈合情况、生长因子、炎症指标、不良反应。结果 观察组创面愈合时间〔（11.28±2.12）d〕及创面皮肤血运恢复时间〔（17.54±2.27）d〕短于对照组〔（17.41±3.05）d、（22.60±3.41）d〕（P＜0.05）；相较于治疗前，治疗后两组血清成纤维细胞生长因子（bFGF）、转化生长因子-β1（TGF-β1）、表皮生长因子（EGF）水平增加，且观察组高于对照组（P＜0.05）；两组肿瘤坏死因子-α（TNF-α）、白细胞介素（IL）-6、IL-10水平降低，且观察组低于对照组，差异有统计学意义（P＜0.05）。两组瘙痒、红斑、丘疹不良反应总发生率比较，差异无统计学意义（P＞0.05）。结论 rhEGF凝胶联合水凝胶敷料可加快烧伤后瘢痕皮肤软组织扩张术后患者创面愈合，且对生长因子水平及炎症指标改善效果良好，安全性较好。

Abstract:

Objective To investigate the effect of recombinant human epidermal growth factor (rhEGF) gel combined with hydrogel dressing on patients underwent scar skin and soft tissue expansion surgery after burn injury.Methods Using a random number table method, 92 patients who underwent scar skin and soft tissue expansion surgery after burn injury admitted in Jiangnan University Affiliated Hospital from August 2021 to August 2024 were divided into two groups, with 46 patients in each group. The patients in the control group were applied with hydrogel dressing, and the patients in the observation group were applied with hydrogel combined with rhEGF gel. After 3 weeks of treatment, the wound healing, growth factors, inflammatory indicators and adverse reactions were compared between the two groups.Results The observation group had a shorter wound healing time 〔 (11.28±2.12) d 〕 and wound skin blood circulation recovery time 〔 (17.54±2.27) d 〕 compared to the control group 〔 (17.41±3.05) days, (22.60±3.41) days 〕. Compared with before treatment, the levels of serum fibroblast growth factor (bFGF), transforming growth factor-β1 (TGF-β1), and epidermal growth factor (EGF) increased in both groups after treatment, and the observation group was higher than the control group (P＜0.05); The levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL), and IL-10 decreased in both groups, and the observation group was lower than the control group (P＜0.05). There was no significant difference in the total incidence of pruritus, erythema and papules between the two groups (P＞0.05).Conclusion rhEGF gel combined with hydrogel dressing can accelerate the wound healing of patients underwent scar skin and soft tissue expansion surgery after burn injury, and improve the level of growth factors and inflammatory indicators, with good safety.