Abstract:Objective To explore the curative effect of aspirin and atorvastatin calcium combined with intracranial vascular intervention in the treatment of elderly patients with ischemic cerebrovascular disease (ICVD) and its impact on neurological function.Methods A total of 140 elderly patients with ICVD admitted to Luoyang Sixth People's Hospital from December 2021 to December 2023 were selected and divided into the control group (n=70,treated with aspirin and atorvastatin calcium tablets) and the observation group (n=70,treated with aspirin and atorvastatin calcium combined with intracranial vascular intervention) according to the random number table method. The clinical efficacy, neurological function [National Institutes of Health Stroke Scale (NIHSS)], hemodynamic parameters [mean blood flow velocity (Vm), systolic peak flow velocity (Vs), and end diastolic flow velocity (Vd)], quality of life, and adverse reactions were compared between the two groups.Results The total effective rate in the observation group was higher than that in the control group(P<0.05); The NIHSS score after treatment in the observation group (6.69±0.74) was lower than that in the control group (10.11±1.18) (P<0.05); The Vs (100.22±16.28) cm/s, Vd (20.34±4.14) cm/s, and Vm (68.29±5.78) cm/s in the observation group after treatment were lower than those in the control group[(134.29±18.46) cm/s, (33.69±5.03) cm/s, and (72.39±5.14) cm/s, respectively] (P<0.05); After treatment, the quality of life scores of the observation group were higher than those of the control group, and the difference was statistically significant (P<0.05). The incidence of adverse events in the observation group (4.29%) was lower than that in the control group (15.71%) (P<0.05). Conclusion Aspirin and atorvastatin calcium combined with intracranial vascular interventional therapy can effectively improve vascular occlusion, hemodynamics, cerebral nerve function, improve the quality of life of elderly patients with ICVD, and has high safety.