阿司匹林及阿托伐他汀钙联合颅内血管介入治疗老年缺血性脑血管病患者效果观察

Effect of aspirin and atorvastatin calcium combined with intracranial vascular intervention in the treatment of elderly patients with ischemic cerebrovascular disease

摘要:

目的 探究阿司匹林及阿托伐他汀钙联合颅内血管介入治疗老年缺血性脑血管病（ICVD）患者的疗效及对神经功能的影响。方法 选择洛阳市第六人民医院2021年12月至2023年12月收治的140例老年ICVD患者，根据随机数字表法分为对照组（n=70，采用阿司匹林与阿托伐他汀钙片治疗）与观察组（n=70，采用阿司匹林及阿托伐他汀钙联合颅内血管介入治疗）。对比两组临床疗效、神经功能〔美国国立卫生研究院卒中量表（NIHSS）〕、血流动力学指标〔平均血流速度（Vm）、收缩期峰值流速（Vs）、舒张末期流速（Vd）〕、生活质量及不良反应。结果 观察组总有效率较对照组高（P＜0.05）；观察组治疗后NIHSS评分〔（6.69±0.74）分〕较对照组[（10.11±1.18）分〕低（P＜0.05）；观察组治疗后Vs〔（100.22±16.28）cm/s]、Vd[（20.34±4.14）cm/s]、Vm[（68.29±5.78）cm/s]低于对照组的（134.29±18.46）cm/s、（33.69±5.03）cm/s、（72.39±5.14）cm/s（P＜0.05）；治疗后，观察组生活质量评分均高于对照组，差异有统计学意义（P＜0.05）；观察组不良事件发生率（4.29%）较对照组（15.71%）低，差异有统计学意义（P＜0.05）。结论 阿司匹林及阿托伐他汀钙联合颅内血管介入治疗老年ICVD患者能有效改善其血管堵塞状况，改善血流动力学、脑神经功能，提高患者生活质量，且安全性高。

关键词:缺血性脑血管病; 老年; 颅内血管介入疗法; 神经功能; 血流动力学; 不良反应

Abstract:

Objective To explore the curative effect of aspirin and atorvastatin calcium combined with intracranial vascular intervention in the treatment of elderly patients with ischemic cerebrovascular disease (ICVD) and its impact on neurological function.Methods A total of 140 elderly patients with ICVD admitted to Luoyang Sixth People's Hospital from December 2021 to December 2023 were selected and divided into the control group (n=70,treated with aspirin and atorvastatin calcium tablets) and the observation group (n=70,treated with aspirin and atorvastatin calcium combined with intracranial vascular intervention) according to the random number table method. The clinical efficacy, neurological function [National Institutes of Health Stroke Scale (NIHSS)], hemodynamic parameters [mean blood flow velocity (Vm), systolic peak flow velocity (Vs), and end diastolic flow velocity (Vd)], quality of life, and adverse reactions were compared between the two groups.Results The total effective rate in the observation group was higher than that in the control group(P＜0.05); The NIHSS score after treatment in the observation group (6.69±0.74) was lower than that in the control group (10.11±1.18) (P＜0.05); The Vs (100.22±16.28) cm/s, Vd (20.34±4.14) cm/s, and Vm (68.29±5.78) cm/s in the observation group after treatment were lower than those in the control group[(134.29±18.46) cm/s, (33.69±5.03) cm/s, and (72.39±5.14) cm/s, respectively] (P＜0.05); After treatment, the quality of life scores of the observation group were higher than those of the control group, and the difference was statistically significant (P＜0.05). The incidence of adverse events in the observation group (4.29%) was lower than that in the control group (15.71%) (P＜0.05). Conclusion Aspirin and atorvastatin calcium combined with intracranial vascular interventional therapy can effectively improve vascular occlusion, hemodynamics, cerebral nerve function, improve the quality of life of elderly patients with ICVD, and has high safety.

Key words:Ischemic cerebrovascular disease; Elderly; Intracranial vascular intervention therapy; Neurological function; Hemodynamics; Adverse reactions